Current Issue : October-December Volume : 2013 Issue Number : 4 Articles : 4 Articles
The aim of the present study was to develop chronomodulated drug delivery by using the principles of compression coat. Compression coated tablets of lercanidipine were prepared by direct compression method using chitosan. Tablets were evaluated for their physicochemical properties and in vitro drug release studies. Research is based on chronopharmacological phenomena and this demonstrates that the time of administration is a possible factor in variation of the pharmacokinetics of a drug. the coating thickness delays the drug release and prevents the drug release from the core by acting as a shield....
Ciprofloxacin hydrochloride exhibits poor flow properties and compressibility. To prepare crystal agglomerates, an acetone: dichloromethane: water system was used, where dichloromethane acted as bridging liquid, water and acetone as good and bad solvents respectively. The proportion of this solvent system was selected from ternary phase diagram. Polyvinyl Pyrrolidone was also used along with drug solution in water, to improve agglomerate strength. The effect of agitation speed, time of agitation and temperature of system was also determined. The agglomerates were characterized by Infra-Red spectroscopy, TLC, X-ray diffraction, differential scanning calorimetry and scanning electron microscopy. Micromeritic properties like true, bulk and tapped densities, angle of repose, Carr’s index, particle size and spherical index were determined. Crystal agglomerates of Ciprofloxacin hydrochloride showed improvement in flowability, packability and compressibility. The results of micromeritic properties and Heckel’s analysis confirmed an improvement in compressibility of crystal agglomerates [1, 3] when compared to plain Ciprofloxacin Hydrochloride. The resultant agglomerates was directly compressed into tablets and evaluated for tablet properties. Stability studies of these tablets were also carried out for a period of four weeks. Directly compressible agglomerates of Ciprofloxacin Hydrochloride, having excellent flow properties and compressibility was prepared by spherical crystallization technique....
Oral solid dosage form are the most stable dosage form as it has highest accuracy in dosage regimen. There are number of technologies which gives quick result with accuracy in minimum time with most stable product with number of advantages having low cost medicines and greater bio availablity. These technologies emerges as a revolution in pharmaceutical sector for different products....
According to the International Conference on Harmonization guidelines on impurities in new drug substances, an impurity is defined as any component of the new drug substance that is not the chemical entity defined as the new drug substance. Impurities can be formed during drug synthesis, manufacturing and/or storage. Impurity profiling helps in detection, identification and quantification of various types of impurities as well as residual solvents in bulk drugs and in pharmaceutical formulations. There are different chromatographic and related separation methods, spectroscopic and hyphenated techniques for detecting and characterizing impurities. The advent of hyphenated techniques has not only separation but structural identification of impurities as well. Among all hyphenated techniques the most exploited techniques for impurity profiling of drug are LC-MS-MS, LC-NMR, LC-NMR-MS, GC-MS AND LC-MS. Various regulatory authorities like ICH, USFDA, Canadian Drug and Health Agencies are emphasizing on the purity requirements and on identification of impurities in active pharmaceutical ingredients as presence of impurities even in small amounts may influence the efficacy and safety of the pharmaceutical products. Thus enlightening the need of impurity profiling of drug substances in pharmaceutical research, this review focuses on characterisation of the sources of impurities and analytical methods for identification as well as quantification of impurities present in the pharmaceuticals. This is the best way to characterize the quality and stability of bulk and pharmaceutical formulations....
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